Monia Barnat

Research Article View ORCID ProfileMonia Barnat1, View ORCID ProfileMariacristina Capizzi1,*, Esther Aparicio1,*, View ORCID ProfileSusana Boluda2, View ORCID ProfileDoris Wennagel1, View ORCID ProfileRadhia Kacher1, View ORCID ProfileRayane Kassem1, View ORCID ProfileSophie Lenoir1, View ORCID ProfileFabienne Agasse1, View ORCID ProfileBarbara Y. Braz1, View ORCID ProfileJeh-Ping Liu3, View ORCID ProfileJulien Ighil4, View ORCID ProfileAude Tessier5, View ORCID ProfileScott O.

Abstract Although Huntington’s disease is a late-manifesting neurodegenerative disorder, both mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that Huntington’s disease might affect neurodevelopment. To determine whether this is actually the case, we examined tissue from human fetuses (13 weeks gestation) that carry the Huntington’s disease mutation.