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Epigenetic and Cellular Reprogramming of Doxorubicin-Resistant MCF-7 Cells Treated with Curcumin
2. Results and Discussion 2.1. Effects of Curcumin on P-Glycoprotein Expression The MCF-7R cellular model utilized in this study derives from the parental sensitive MCF-7 cell through repeated exposure to gradually increasing concentrations of doxorubicin. This treatment causes constitutive activation of the NF-κB transcription factor, an overexpression of P-gp and other typical factors related to apoptosis inhibition [13,14,15].
Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia
1. Introduction The new therapeutic strategies available today for cancer treatment include targeted therapies, which have significantly increased patient survival [1]. Despite the current and emerging therapeutic landscape for the treatment of cancer and an improved understanding of mechanisms of resistance to conventional therapies [2], primary and secondary drug resistance remains a substantial problem for most patients.
Molecules | Free Full-Text | Recovery of Bioactive Compounds from Marine Organisms: Focus on the Future Perspectives for Pharmacological, Biomedical and Regenerative Medicine Applications of Marine Collagen
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