Monica Varona Baranda on Muck Rack

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Articles

Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation

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By Monica Varona Baranda, Deepika Puri, Alexandra Bott, Esra Dursun Torlak
| biorxiv.org
Wolfgang Wagner is involved in the company Cygenia, which can provide service for epigenetic analysis to other scientists (www.cygenia.com).
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Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape

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By Jessica Iliescu, Sven Liesenfelder, Monica Varona Baranda, Athanasia Mizi
| biorxiv.org
Abstract Aging is reflected by genome-wide DNA methylation changes, but it is largely unclear how these epigenetic modifications are regulated. In this study, we explored the possibility to interfere with epigenetic clocks by epigenetic editing at individual CpG sites. CRISPR-guided approaches (dCas9-DNMT3A and CRISPRoff) facilitated targeted methylation at an age-associated genomic region in PDE4C that remained stable for more than three months.
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