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Loading metrics Open Access Peer-reviewed Research Article Citation: Giannakopoulos S, Pak J, Bakse J, Ward MA, Nerurkar VR, Tallquist MD, et al. (2025) SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone. PLoS Pathog 21(1): e1012804.
Abstract Compromised male reproductive health is one of the symptoms of long COVID with a decrease in male fertility markers including testosterone levels and sperm count for months in recovering patients. However, the long-term impact of SARS-CoV-2 infection on testicular injury and underlying mechanisms remains unknown. We previously demonstrated a disrupted tissue architecture with no evidence of virus replication in the testis during the acute stage of the disease in K18-hACE2 mice.
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