Monir Sadat Hakemi

Abstract Background Dermatomyositis (DM) is a systemic autoimmune disease characterized by distinct skin lesions and a clinically heterogeneous constellation of systemic manifestations. This disease poses a challenge to clinicians because of its rarity, diverse clinical presentations, and variable organ involvement, resulting from an autoimmune attack on affected organs, which could be triggered by environmental factors in genetically susceptible individuals.

Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit.

MAIN TEXT ARTICLE Amir Ahmad Nassiri, Corresponding Author nassirimorad@yahoo.com orcid.org/0000-0002-7339-0965 Division of Nephrology, Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Corresponding author Amir Ahmad Nassiri, MD, Shahid Beheshti University of Medical Sciences, Division of Nephrology, Department of Internal Medicine, Tehran, Iran, Phone: +98-9121719757 Email: nassirimorad@yahoo.com Search for more papers by this author Monir Sadat...