Monta Nakamura

In the original publication, the stereochemistries of the 5′-oxazaphospholidine derivatives 4b–4d were incorrect. Our re-evaluation of the stereochemical pathway of phosphoramidates from 5′-oxazaphospholidine derivatives revealed an inconsistency in the original manuscript. To address this, we conducted a detailed review of the compounds used in this study. Then, we became aware that we utilized (Rp)-5′-oxazaphospholidine derivatives as (Sp)-counterparts, and vice versa.

Introduction Click to copy section linkSection link copied! Nucleoside analogs, widely used as antiviral or anticancer drugs, are taken up by cells and converted into 5′-mono, di-, and triphosphate forms (activated forms) by intracellular kinases. (1,2) The activated forms are usually incorporated into DNA or RNA by polymerases. The structurally different nucleoside moiety terminates the chain elongation, eliciting antiviral or anticancer activity.

Introduction Click to copy section linkSection link copied! Nucleoside analogs, widely used as antiviral or anticancer drugs, are taken up by cells and converted into 5′-mono, di-, and triphosphate forms (activated forms) by intracellular kinases. (1,2) The activated forms are usually incorporated into DNA or RNA by polymerases. The structurally different nucleoside moiety terminates the chain elongation, eliciting antiviral or anticancer activity.