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Montserrat Terrazas on Muck Rack

Montserrat Terrazas

As seen in: MDPI, ACS Publications, BioRxiv
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Articles

Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2+ Breast Cancer

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By Pedro P. Medina, Modesto Orozco, Montserrat Terrazas
| ACS Publications
Design and Synthesis of Decorated LNPs Our dually modified LNP design incorporates six key components: (i) a neutral lipid, DSPC (1,2-distearoyl- sn -glycero-3-phosphocholine); (ii) the ionizable lipid DLin-MC3-DMA; (iii) cholesterol; (iv) DPG-PEG (1,2-dipalmitoyl- rac -glycero-3-methyl polyoxyethylene-2000), a PEG-lipid with two 16-carbon chains; (v) Oct-modified DSPE-PEG 2000 (Oct-DSPE-PEG), where DSPE-PEG is a PEG-lipid with two longer C18 alkyl chains that favor stable conjugate...
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Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2+ Breast Cancer

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By Pedro P. Medina, Modesto Orozco, Montserrat Terrazas
| dx.doi.org
Introduction Click to copy section linkSection link copied! Oligonucleotide (ON) therapeutics, (1−9) including antisense oligonucleotides (ASOs), (6) short interfering RNAs (siRNAs), (7) aptamers, (9) and CRISPR-Cas systems, (8) have revolutionized modern medicine. These therapies allow for the precise modulation or inhibition of gene expression across the entire human genome, making it possible to target proteins that are usually unreachable to small molecule drugs.
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Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism

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By Vito Genna, Guillem Portella, Alba Sala, Montserrat Terrazas
| BioRxiv
Abstract By combining in-silico, biophysical and in-cellulo experiments, we decipher the topology, physical and potential biological properties of hybrid-parallel nucleic acids triplexes; an elusive structure at the basis of life. We found that hybrid triplex topology follows a stability order: r(Py)-d(Pu)·r(Py)> r(Py)-d(Pu)·d(Py)> d(Py)-d(Pu)·d(Py)> d(Py)-d(Pu)·r(Py).
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