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Mora Barthelmess

As seen in: MDPI, Genome Medicine, Cancer Research
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Articles

Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD-1 Immunotherapy | Cancer Research | American Association for Cancer Research

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By Van Damme, Mora Barthelmess, Van Craenenbroeck, De Groof
| Cancer Research Verified
To assist their growth and metastasis, tumors skew normal biological processes to their benefit. For instance, regulatory T cells (Treg) maintain homeostasis by suppressing autoreactive effector T cells, preventing autoimmunity (1, 2). However, in a tumor context, Tregs promote tumor growth through their suppression of antitumor T-cell responses (3, 4). Consequently, the high infiltration of Tregs into tumors is correlated with a lower overall survival in multiple cancer types (5, 6).
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Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD1 Immunotherapy

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By Van Damme, Mora Barthelmess, Van Craenenbroeck, De Groof
| Cancer Research Verified
This content is only available via PDF. This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License .
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Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment - Genome Medicine

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By Mora Barthelmess, Van Ginderachter, Vrije Universiteit Brussel, Cancer Immunotherapy
| link.springer.com
Abstract Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of transcription factor binding and thereby play an important role in controlling transcriptional responses to the tissue environment.
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