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Mora Barthelmess

As seen in: MDPI, Genome Medicine, Cancer Research
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Articles

Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD-1 Immunotherapy | Cancer Research | American Association for Cancer Research

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By Van Damme, Mora Barthelmess, Van Craenenbroeck, De Groof
| Cancer Research Verified
To assist their growth and metastasis, tumors skew normal biological processes to their benefit. For instance, regulatory T cells (Treg) maintain homeostasis by suppressing autoreactive effector T cells, preventing autoimmunity (1, 2). However, in a tumor context, Tregs promote tumor growth through their suppression of antitumor T-cell responses (3, 4). Consequently, the high infiltration of Tregs into tumors is correlated with a lower overall survival in multiple cancer types (5, 6).
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Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD1 Immunotherapy

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By Van Damme, Mora Barthelmess, Van Craenenbroeck, De Groof
| Cancer Research Verified
This content is only available via PDF. This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License .
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Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment - Genome Medicine

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By Mora Barthelmess, Van Ginderachter, Vrije Universiteit Brussel, Cancer Immunotherapy
| Genome Medicine Verified
References Guilliams M, Mildner A, Yona S. Developmental and Functional Heterogeneity of Monocytes. Immunity. 2018;49:595–613. CAS PubMed Google Scholar Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O’Brien S, et al. Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Science Translational Medicine. 2019;11:eaat1500-16. CAS PubMed PubMed Central Google Scholar Olingy CE, Dinh HQ, Hedrick CC.
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