Morgane Lacour on Muck Rack

Morgane Lacour

As seen in: Nature, Genome Medicine
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Articles

Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios

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By Aline Zaréa, Kévin Cassinari, François Lecoquierre, Olivier Quenez, Camille Charbonnier, Catherine Schramm, Morgane Lacour, Stéphane Rousseau, Magalie Lecourtois, Robert Olaso, Anne Boland, Jean-Francois Deleuze, Christian Gilissen, Joris A Veltman, Lisenka ELM Vissers, Céline Bellenguez, John Hardy, Henne Holstege, Marc Hulsman, Jean-Charles Lambert, Simon Mead, Alfredo M. Ramirez, Alfredo Ramírez, Rebecca Sims, John van Swieten, Michael Wagner, Julie Williams, Stéphanie Bombois, Claire Boutoleau-Bretonnière, Vincent Deramecourt, Frédérique Etcharry-Bouyx, Audrey Gabelle, Gwenaël Le Guyader, Isabelle Le Ber, Thibaud Lebouvier, Olivier Martinaud, Chloé Quélin, Marie Sarazin, Christel Thauvin-Robinet, David Wallon, Gaël Nicolas, Anne-Claire Richard, Anne Rovelet-Lecrux, Orio Dols-Icardo, Ludivine Charmard-Witkowski, Vincent de la Sayette, Claude Gueriot, Agnès Michon, Mathieu Sévin
| Nature
Abstract The genetic architecture of sporadic Early-Onset Alzheimer Disease (sEOAD, onset ≤65 years) remains largely unknown. To assess the de novo mutation (DNM) hypothesis, we performed a nationwide recruitment of 37 novel sEOAD patients–unaffected parents trios. After assessing known monogenic genes, we performed trio-based exome sequencing and jointly analyzed novel trios with 12 previously reported ones. Of these, we selected 16 trios for genome sequencing.
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