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Articles by Morley JE
Physical activity and injurious falls in older Australian women: adjusted associations and modification by physical function limitation and frailty in the Australian Longitudinal Study on Women’s Health
Abstract To investigate associations between leisure-time physical activity (LPA) and injurious falls in older women and explore modification of associations by physical function and frailty. Women born during 1946–51 from the Australian Longitudinal Study on Women’s Health, injurious falls (self-reported fall with injury and/or medical attention) and self-reported weekly LPA (duration and type).
Editorial: Screening for Malnutrition (Undernutrition) in Primary Care.
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Editorial: Bidirectional Communication Between Brain and Muscle.
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The future of sarcopenia.
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Editorial: Autonomic Neuropathy and Cardiovascular Disease in Aging.
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Obesity in the Elderly
As the proportion of population above age 65 grows, so too increases the prevalence of those individuals who are obese. This phenomenon of an elderly population with obesity is the source of much research and debate with regards to treatment recommendations. It appears that obesity confers an increased risk of mortality to those subjects on the extreme ends of the BMI spectrum, those who are underweight and those who are morbidly obese.
A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans.
Representative sample of African Americans age 49 to 65 years at onset of study. The 5-item FRAIL scale (fatigue, resistance, ambulation, illnesses, and loss of weight), at baseline and activities of daily living (ADLs), instrumental activities of daily living (IADLs), mortality, short physical performance battery (SPPB), gait speed, one-leg stand, grip strength and injurious falls at baseline and 9 years. Blood tests for CRP, SIL6R, STNFR1, STNFR2 and 25 (OH) vitamin D at baseline.
Patient-Centered Care and Cognitive Dysfunction.
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Alzheimer Disease.
Alzheimer disease is due to increased amyloid-β coupled with low progranulin. Several brain imaging techniques are helpful in the diagnosis. Drugs available for treating Alzheimer disease have limited clinical utility. Cognitive stimulation therapy is an effective therapy for persons with moderate Alzheimer disease.
An Overview of Cognitive Impairment.
Cognitive decline occurs in all persons during the aging process. Eventually, this can result in mild cognitive impairment and dementia. There are more than 100 causes of dementia. A multifocal approach to slowing cognitive decline (Mediterranean diet, exercise, computer games, socialization, and treatment of cardiovascular risk factors) appears to be effective.
A physiological role for amyloid-beta protein:enhancement of learning and memory.
Amyloid-beta protein (Abeta) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of Abeta and its physiological role in non-disease states is not clear. In these studies, low doses of Abeta enhanced memory retention in two memory tasks and enhanced acetylecholine production in the hippocampus in vivo.
F3ALLS Approach to Preventing Falls.
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Editorial: Nonpharmacological Treatment of Cognitive Impairment.
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Editorial: Dysphagia, Dementia and Frailty.
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Editorial: Defining Undernutrition (Malnutrition) in Older Persons.
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A Decade of JAMDA.
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Editorial: Weight Loss is a Major Cause of Frailty.
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Myopenia and precision (P4) medicine.
Precision (P4) medicine represents a new medical paradigm that focuses on Personalized, Predictive, Preventive and Participatory approaches. The P4 paradigm is particularly appropriate for moving the care of persons with myopenia forward. Muscular dystrophies are clearly a set of genetically different diseases where genomics are the basis of diagnosis, and genetic modulation via DNA, oligonucleotides and clustered regularly interspaced short palendronic repeats hold great potential for a cure.
Diabetes: The diabetic brain.
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Frailty Fantasia.
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JAMDA Maintains Excellent Impact Factor.
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Rapid Geriatric Assessment: Secondary Prevention to Stop Age-Associated Disability.
The Rapid Geriatric Assessment (RGA) measures frailty, sarcopenia, anorexia, cognition, and advanced directives. The RGA is a screen for primary care physicians to be able to detect geriatric syndromes. Early intervention when geriatric syndromes are recognized can decrease disability, hospitalization, and mortality.
The Geriatrician Circa 2030.
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Management of Comorbidities in Older Persons With Type 2 Diabetes.
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Integrated Care: Enhancing the Role of the Primary Health Care Professional in Preventing Functional Decline: A Systematic Review.
Although the older population is increasing worldwide, there is a marked deficit in the number of persons trained in geriatrics. It is now recognized that early detection and treatment of geriatric syndromes (frailty, sarcopenia, anorexia of aging, and cognitive decline) will delay or avert the development of disability. To identify simple screening programs available for primary health professionals to identify geriatric syndromes. PubMed for the last 5 years and study authors.
Hormones and Sarcopenia
Sarcopenia is defined as the loss of muscle mass associated with a loss of muscle function, e.g., walking speed. A number of consensus definitions exist for sarcopenia with cut-off points being ethnically specific. A rapid screen test (SARC-F) is available and does not require different ethnic cut-off points. Sarcopenia leads to the development of frailty, disability and mortality. The prevalence of sarcopenia varies from 1-29% in community-dwelling and 14 to 33% in long-term care populations.
Dysphagia: A New Geriatric Syndrome.
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Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia.
The anorexia of aging was first recognized as a physiological syndrome 30 years ago. Its major causes are an alteration in fundal compliance with an increase in antral stretch and enhanced cholecystokinin activity leading to increased satiation.This anorexia leads to weight loss in aging persons and is one of the component causes of the aging related sarcopenia.
Geriatricians: The Super Specialists.
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The Future of Long-Term Care.
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Rapid Geriatric Assessment: A Tool for Primary Care Physicians.
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The Effectiveness and Harms of Antidepressants.
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Nutrition and Aging Well
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Screening for and Managing the Person with Frailty in Primary Care: ICFSR Consensus Guidelines
doi: 10.1007/s12603-020-1492-3. Affiliations Affiliation 1 John E. Morley, MB, BCh, Division of Geriatric Medicine, Saint Louis University, SLUCare Academic Pavilion, Section 2500 1008 S. Spring Ave., 2nd Floor, St. Louis, MO 63110, USA, Email: john.morley@health.slu.edu, Twitter: @drjohnmorley. PMID: 33155616 PMCID: PMC7597431 DOI: 10.1007/s12603-020-1492-3 Free PMC article Item in Clipboard J Nutr Health Aging. Free PMC article Display options Format doi: 10.1007/s12603-020-1492-3.
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