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Motlik Jan

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Articles

Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model

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By Michaela Vaskovicova, Josep M. Cambra, Andrea Bähr, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Tarik Bozoglu, Vijayanand Rajendran, Tatjana Dorn, Jessica Hernandez, Magdalena Harakalova, Peter van Tintelen, Jana Juhásová, Steffanie Senf, Francesca Stillitano, Joost P. G. Sluijter, Mathias Ritzmann, Zdenka Ellederova, Pieter A. Doevendans, David Drutovic, Pieter Glijnis, Eckhard Wolf, Christian Kupatt, Nikolai Klymiuk, Petra Runa-Vochozkova, Eva-Maria Männer, Tuna Güngör, Heinke C. Heymer, Mara L. Corsten, Solomon K. Yator, Ina M. Luksch, Stefan Juhas, Carolina G. Cabrera-Gómez, Susanne Zöls, Motlik Jan
| Nature Verified
Abstract Complex diseases such as progressive cardiomyopathies are often insufficiently recapitulated in small animals or in vitro models. Large animal species such as pigs provide a valuable alternative, but constitutive genetic manipulation has not yet been applied to pigs in an effective manner, mainly due to biological and logistical limitations.
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