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Articles

Escitalopram and NHT normalized stress-induced anhedonia and molecular neuroadaptations in a mouse model of depression

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By Or Burstein, Motty Franko, Eyal Gale, Assaf Handelsman
| PLOS
Anhedonia is defined as a diminished ability to obtain pleasure from otherwise positive stimuli. Anxiety and mood disorders have been previously associated with dysregulation of the reward system, with anhedonia as a core element of major depressive disorder (MDD). The aim of the present study was to investigate whether stress-induced anhedonia could be prevented by treatments with escitalopram or novel herbal treatment (NHT) in an animal model of depression.
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