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Moujian Guo on Muck Rack

Moujian Guo

As seen in: Nature
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Articles

The risk of human- and mammal-infecting tick-borne viruses in northwest China and adjacent countries - Nature Communications

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By Hong Zhou, Hengcong Liu, Yun-Xiao Wang, Shanshan Zhao, Moujian Guo, Mingxue Cui, Jianjun Chen, Juan Li, Suwen Wang, Xudong Zhang, Jiaqi Qin, Ziman Lv, Zhenghai Ma, Ruiling Zhang, Bin Zhang, Wen Zheng, Jingkai Ji, Tianze Wang, Edward C. Holmes, Yuan-Zhi Wang
| Nature Verified
Abstract The prevalence, evolution, and disease risk of pathogenic tick-borne viruses (TBVs) remains poorly understood in northwest China and adjacent countries, which are endemic for several TBVs of public health importance.
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Zika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA - Nature Communications

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By Wei Yang, Hanyu Li, ShanShan Wang, Shanshan Wang, Rui Huang, Yifei Zhang, Shihua Li, Ruirui Yang, Yuxin Xiong, Yifei Liu, Wei Xiao, Moujian Guo, Dingran Zhao, Mengjing Huang
| Nature Verified
Abstract ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells’ ability to produce testosterone, leading to decreased sperm counts and motility.
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