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Characterization of antibody response to increasingly extreme conditions such as elevated temperatures, low pH, or co-solvation with various chemicals provides a means to screen for potential challenges in developing a production process and stable formulation for an antibody [1], [2], [3], [4], [5].
In malignant cancers, molecularly targeted therapy is attractive because it may not cause the side effects usually associated with chemotherapy. The search for proteins that inhibit the regulation of multiple oncogenic pathways is particularly urgent because tumor cells have many selective ways to survive and proliferate, and blocking only one molecular pathway may be futile.
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