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Articles

Replication‐induced DNA secondary structures drive fork uncoupling and breakage

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By Sophie Williams Verified, Corella S. Casas-Delucchi, Federica Raguseo, MSRH London
| embopress.org
Introduction Eukaryotic DNA replication is a highly regulated process carried out by a complex molecular machine known as the replisome (Bell & Labib, 2016). Parental duplex DNA is unwound by the replicative helicase, CMG, and nascent DNA is subsequently synthesised by polymerase ε on the leading strand, or polymerase δ on the lagging strand.
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