Muaz Nik Rushdi on Muck Rack

Muaz Nik Rushdi

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Articles

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination - Nature Communications

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By Hyun-Kyu Choi, Peiwen Cong, Kaitao Li, Wei Chen, Jizhong Lou, Michelle Krogsgaard, Muaz Nik Rushdi
| Nature Verified
Abstract The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to analyze 55 datasets, demonstrating the models’ ability to quantitatively integrate and classify a broad range of bond behaviors and biological activities.
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