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Mubarik Burki on Muck Rack

Mubarik Burki

As seen in: Nature
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Articles

Moesin integrates cortical and lamellar actin networks during Drosophila macrophage migration - Nature Communications

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By Besaiz J. Sánchez-Sánchez, Stefania Marcotti, David Salvador-Garcia, Mubarik Burki, Andrew Davidson, Will Wood, María-del-Carmen Díaz-de-la-Loza
| Nature Verified
Abstract Cells are thought to adopt mechanistically distinct migration modes depending on cell-type and environmental factors. These modes are assumed to be driven by mutually exclusive actin cytoskeletal organizations, which are either lamellar (flat, branched network) or cortical (crosslinked to the plasma membrane).
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Persistent and polarized global actin flow is essential for directionality during cell migration

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By Lawrence Yolland, Brian M. Stramer, Mubarik Burki, Stefania Marcotti
| Nature Verified
Abstract Cell migration is hypothesized to involve a cycle of behaviours beginning with leading edge extension. However, recent evidence suggests that the leading edge may be dispensable for migration, raising the question of what actually controls cell directionality. Here, we exploit the embryonic migration of Drosophila macrophages to bridge the different temporal scales of the behaviours controlling motility.
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