Mufuliat Toyin on Muck Rack

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Articles

A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein

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By South Kensington, Sabrina Yahiya, Mufuliat Toyin
| The Company of Biologists
To enable identification of cellular target(s) via PAL, we first derivatised DDD01035881 and the related compound DDD01028076, N-4HCS compounds discovered in the initial screen (Delves et al., 2018), to incorporate both a photoactivatable group and clickable alkyne moiety. An alkyne handle and aryl azide moiety were separately incorporated onto the N-4HCS scaffold to yield photoaffinity probe 2.
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