Mujde Can Ibanoglu

Objective Intrahepatic cholestasis of pregnancy (ICP) manifests in late pregnancy. Elevated serum bile acid is a diagnostic criterion: however, its measurement is troublesome. Prediction of ICP by blood markers is not established. Serum bile acid level is associated with liver damage and inflammation.

Introduction Preeclampsia (PE) is a pregnancy-related disease that occurs after the 20th gestational week, characterized by clinical symptoms such as hypertension, proteinuria, poor placental vascularization, abnormal maternal cardiovascular adaptations, and fetal growth restriction. PE is the leading cause of maternal and fetal mortality and morbidity worldwide, affecting up to 10% of pregnancies (1, 2). The underlying mechanism and preventive treatment for PE are still under investigation.