Munazza Khan

Pakistan is caught in a catastrophic flood crisis. In the riverine plains of Punjab and Sindh, the Khyber Pakhtunkhwa and Gilgit-Baltistan northern valleys, monsoon rains and distended rivers have moved millions of people, drowned thousands of villages and killed hundreds of people. The destruction itself is not very well distributed. The most severe impact of this climate disaster is being experienced by women, especially in rural and low-income societies.

Abstract Mechanisms underlying breast cancer brain metastasis (BCBM) are still not well understood. Here, we identified that BCBM patient serum contained extracellular vesicles (EVs) with high levels of microRNAs (miRNAs)-107 and -425. Levels of miR-107 and miR-425 were elevated in brain metastases, and the elevation was associated with poor patient prognoses.

Abstract Breast cancer is the most frequent malignancy in women, constituting 15.2% of all new cancers diagnosed in the United States. Distant breast cancer metastasis accounts for the majority of breast cancer-related deaths; brain metastasis is the third most common site for metastatic breast cancer but is associated with worst prognosis of approximately eight months of survival. Current treatment options for breast cancer brain metastasis (BCBM) are limited and ineffective.