Muthipeedika Nibin Joy

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the supplementary material of this article. Supporting Information Filename Description ejoc70765-sup-0001-SuppData-S1.pdf4.4 MB The detailed experimental procedure for the synthesis of compounds and their spectroscopic characterization is available in the Supporting Information uploaded along with the manuscript.

1. Introduction The presence of highly reactive free radicals and oxygen species in the human body can cause numerous degenerative diseases [1,2,3] such as aging, atherosclerosis, cancer etc. One important reason for this issue is the fact that free radicals can abstract hydrogen atoms from membranes, lipids or DNA existing in biological systems [4]. In this scenario, the significance of eliminating free radicals from biological system has emerged as an urgent need.

2. Results and Discussion 2.1. Chemistry The synthesis of target compounds 3a–t, 5a–o, 6a–n, and 7a–f has been previously reported by us [,,], as depicted in . Initially, we took 4-methyl-7-hydroxy coumarin 1 as the starting material and treated it with propargyl bromide in K2CO3 to obtain the O-propargylated product 2.