Mutsuki Sato

1. Introduction 1.1. Research Backgound In recent major earthquakes in Japan, such as the Tohoku Region Pacific Ocean Earthquake (the Great East Japan Earthquake) in 2011 and the Kumamoto Earthquake in 2016, a considerable number of buildings were demolished due to global inclination caused by pile foundation damage, even though the superstructure sustained only minor damage [1,2].

Introduction Silicon belongs to the same group 14 elements as carbon. However, silicon differs from carbon in several characteristics. Due to these characteristics, silicon switches are known to replace carbon in bioactive compounds with silicon.1, 2 From these studies, it is widely recognised that the introduction of silicon into a compound improves its liposolubility. This is expected to lead to changes in physical properties such as solubility and membrane permeability.