Mutsuyo Hayashi on Muck Rack

Mutsuyo Hayashi

As seen in: ACS Publications
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Articles

Development of Photoredox Cross-Electrophile Coupling of Strained Heterocycles with Aryl Bromides Using High-Throughput Experimentation for Library Construction

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By Ryuma Sato, Yukiko Mori, Mutsuyo Hayashi, Kuninori Tai
| ACS Publications
Microscale high-throughput experimentation was used to develop a photoredox-assisted reductive cross-coupling reaction of aryl halides with strained aliphatic heterocycles facilitated via a ring-opening reaction. This methodology was found to be applicable to medicinally relevant substrates including Boc-protected strained aliphatic heterocycles and (hetero)aryl bromides and was used for compound library construction via parallel medicinal chemistry.
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