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Muzaffer Ahmad Kassab on Muck Rack

Muzaffer Ahmad Kassab

As seen in: Nature, Texas Medical Center
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Articles

"RNA 2′-O-Methylation Promotes Persistent R-Loop Formation and Aid-Medi" by Muzaffer Ahmad Kassab, Yibin Chen et al.

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By Muzaffer Ahmad Kassab, Yibin Chen, Xin Wang, Eric Brown
| Texas Medical Center
BACKGROUND: RNA-DNA hybrids or R-loops are associated with deleterious genomic instability and protective immunoglobulin class switch recombination (CSR). However, the underlying phenomenon regulating the two contrasting functions of R-loops is unknown. Notably, the underlying mechanism that protects R-loops from classic RNase H-mediated digestion thereby promoting persistence of CSR-associated R-loops during CSR remains elusive.
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PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

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By Qian Chen, Françoise Dantzer, Xiaochun Yu, Muzaffer Ahmad Kassab
| Nature Verified
To study the molecular mechanism of PARP2-mediated PAR polymerization, we thoroughly examined PARP2-dependent PARylation induced by hydrogen peroxide (H O ) in wild-type mouse embryonic fibroblasts (MEFs) versus Parp2−/− MEFs using a panel of complementary approaches aimed to decipher the biochemistry of PAR (Fig. 1a).
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