Mythili Padavu

Abstract In response to environmental stress, eukaryotic cells reversibly form functional amyloid aggregates, called amyloid bodies (A-bodies). While these solid-like biomolecular condensates share many biophysical characteristics with pathological amyloids, A-body are non-toxic, and induce a protective state of cellular dormancy. As a recently identified structure, the modulators of A-body biogenesis remain uncharacterized, with the seeding noncoding RNA being the only known regulatory factor.