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Myung Chul Choi on Muck Rack

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Inhibition of Human Amylin Aggregation and Cellular Toxicity by Lipoic Acid and Ascorbic Acid

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By Hyunwoo Jang, Myung Chul Choi, Habiba Alsafar, Suryani Lukman
| American Chemical Society
More than 30 human degenerative diseases result from protein aggregation such as Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM). Islet amyloid deposits, a hallmark in T2DM, are found in pancreatic islets of more than 90% of T2DM patients. An association between amylin aggregation and reduction in β-cell mass was also established by post-mortem studies. A strategy in preventing protein aggregation-related disorders is to inhibit the protein aggregation and associated toxicity.
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