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Nabarun Nandy on Muck Rack

Nabarun Nandy

As seen in: BioRxiv
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Articles

Ovarian germline stem cell dedifferentiation is cytoneme-dependent

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By Catherine Sutcliffe, Hilary L. Ashe, Scott G. Wilcockson, Nabarun Nandy
| BioRxiv
Abstract Progenitor cell dedifferentiation is important for stem cell maintenance during tissue repair and age-related stem cell decline. Here, we use Drosophila ovarian germ cells as a model to study the role of cytonemes in BMP signalling-directed dedifferentiation to germline stem cells. We provide evidence that differentiating germ cell cysts extend cytonemes towards the niche during dedifferentiation to reactivate BMP signalling.
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