Nadia Nasser Petersen

1 Introduction The burden of disease from hepatitis C virus (HCV) infection is significant. Approximately 59 million people are persistently infected globally [1], 20% of whom are in Sub-Saharan Africa [2]. In South Africa (SA), prevalence is under-studied, but an estimated 600,000 people have chronic infection [3].

Abstract Modern retrosynthetic analysis in organic chemistry is based on the principle of polar relationships between functional groups to guide the design of synthetic routes.1 This method, termed polar retrosynthetic analysis, assigns partial positive (electrophilic) or negative (nucleophilic) charges to constituent functional groups in a complex molecules followed by disconnecting bonds between opposing charges.2–4 While this approach forms the basis of undergraduate curriculum in organic...