Skip to main content
Nagendran Tharmalingam on Muck Rack

Nagendran Tharmalingam

As seen in: Nature, Frontiers, BioRxiv
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Nagendran

Contact Nagendran, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Candesartan cilexetil disrupts methicillin-resistant Staphylococcus aureus membrane and potentiates gentamicin and polymyxin B activity

|
By Nagendran Tharmalingam, Robert Kovacs, Róbert Kovács Verified, Philip Baldwin, Harikrishna Sekar Jayanthan, Kulandaisamy Arulsamy, Katherine E. Manz, Joseph A. DeGiorgis, Orlando Acevedo, Michael Gilmore, Steven J. Ludtke, Kurt D. Pennell, Frederick M. Ausubel, Eleftherios Mylonakis, Suelen Scarpa de Mello, Rajmohan Rajmuthiah
| Nature Verified
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of bacterial infections, but treatment options are limited due to MRSA multi-drug resistance. The anti-hypertensive drug Candesartan cilexetil (CC) exhibits potent anti-MRSA activity. It permeabilizes the membrane of MRSA cells and potentiates the activity of aminoglycoside antibiotics. Here, we used a variety of methods to elucidate the mechanism by which CC disrupts membrane homeostasis.
Open in Who Shared Issue with article?

Mefloquine reduces the bacterial membrane fluidity of Acinetobacter baumannii and distorts the bacterial membrane when combined with polymyxin B

|
By Nagendran Tharmalingam, Eleftherios Mylonakis, Harikrishna Sekar Jayanthan
| BioRxiv
Abstract Acinetobacter baumannii is a high-priority organism for the development of new antibacterial treatments. We found that the antimalarial medication mefloquine (MFQ) permeabilized the bacterial cell membrane of A. baumannii, decreased membrane fluidity, and caused physical injury to the membrane. MFQ also maintained activity across different pH conditions (PH range 5-8).
Open in Who Shared Issue with article?

Frontiers | Egg yolk antibody combined with bismuth-based quadruple therapy in Helicobacter pylori infection rescue treatment: a single-center, randomized, controlled study

|
By Nagendran Tharmalingam, Aditya Y. Sarode, Sasikala Muthusamy, Ju Luo
| Frontiers
Sha Cheng†, Huan Li†, Ju Luo, Jingshu Chi, Wenfang Zhao, Jiahui Lin and Canxia Xu* Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China Background: The increasing antibiotic resistance is the main issue causing Helicobacter pylori (H. pylori) eradication failure. As a nutritional supplement, Egg Yolk Antibody (Ig Y) provides a new approach for H. pylori infection rescue therapy. Methods: In this randomized, controlled study, 100 H.
Open in Who Shared Issue with article?
See all 6 articles