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Nai-Ju Chan

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Articles

TGF-β1 Directly Sensitizes Capsaicin-Sensitive Lung Vagal Neurons to Promote Airway Hypersensitivity

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By Chun-Chun Hsu, Yueh-Yin Chen, Nai-Ju Chan
| Wiley Online Library Verified
1 Introduction Inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD), are increasingly recognized as disorders driven by complex neuro-immune interactions, in which dysregulation of pulmonary sensory nerves critically shapes disease symptoms and pathophysiology [1-3]. Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine with well-established roles in immune regulation [4], tissue remodeling [5], and fibrosis [6].
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