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Naijiang Liu on Muck Rack

Naijiang Liu

As seen in: Nature, MDPI, Science Magazine, Texas Medical Center
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Articles

A hostile environment for a commensal

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By Naijiang Liu, Renping Zhao, Wei Wong Verified
| Science Magazine Verified
Abstract A high-fat diet impairs the growth of a commensal that produces lipids with anti-obesogenic effects in mice. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily MyD88 is a critical adaptor protein for Toll-like receptor signaling, which is activated by microbial products.
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EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer

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By Naijiang Liu, Renping Zhao, Wei Wong Verified, Xiaojie Shi, Shao-Rui Chen, Hong Zhou Chen, Maria Daniela Santi, Dong Minh Phuong, Tongxin Xie, Frederico O. Gleber-Netto, Rocco Latorre, Nigel W. Bunnett, Chi T. Viet, Moran Amit, Hui-Lin Pan, Yi Ye
| Science Magazine Verified
Editor’s summary Opioids are used to treat the severe pain caused by oral squamous cell carcinoma (OSCC), but tolerance frequently develops. Liu et al. found that inhibitors of the growth factor receptor EGFR, to which OSCC develop resistance, might instead be used to treat the associated pain by targeting tumor-adjacent neurons. In samples from patients and mouse models, EGFR ligands were abundant in OSCC and nearby glial cells.
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T cell polarization and NFAT activation are stiffness dependent and differentially regulated by the channels PIEZO1 and ORAI1

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By Naijiang Liu, Renping Zhao, Wei Wong Verified, Jingnan Zhang
| Science Magazine Verified
Editor’s summary Immune cells are sensitive to the stiffness of the cells that they target. Zhao et al. investigated how substrate stiffness affected the rapid and long-term responses of T cells to target engagement. T cell activation on soft hydrogels or by softened cancer cells impaired cell polarization and nuclear translocation of the transcription factor NFAT1.
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