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Najate Benamer on Muck Rack

Najate Benamer

As seen in: Nature
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Articles

Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model - Communications Medicine

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By Najate Benamer, Chloé Felgerolle, Mauricio Saenz-Roldan, Marie Giorgi, Marie-José Lecomte, Christine Petit, Nicolas Michalski
| Nature Verified
Abstract The autosomal recessive deafness 9 (DFNB9) is caused by mutations in the otoferlin gene that accounts for 2–8% of all inherited deafness cases. In a previous study, we demonstrated that Adeno-associated virus (AAV) gene therapy restored hearing in a preclinical mouse model of profound DFNB9 deafness caused by a frameshift mutation leading to a complete loss of otoferlin expression.
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Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

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By Maria Angulo, Najate Benamer, Marie Vidal, Maddalena Balia
| Nature Verified
Abstract Myelination of projection neurons by oligodendrocytes is key to optimize action potential conduction over long distances. However, a large fraction of myelin enwraps the axons of parvalbumin-positive fast-spiking interneurons (FSI), exclusively involved in local cortical circuits. Whether FSI myelination contributes to the fine‐tuning of intracortical networks is unknown.
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