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Najd M. Aljadeed on Muck Rack

Najd M. Aljadeed

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Articles

Spatial control of NLRP3 inflammasome assembly by membrane lipid composition

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By Paras Anand, Najd M. Aljadeed
| Nature Verified
Abstract The NLRP3 inflammasome has been shown to assemble on multiple organelles, including the mitochondria, endoplasmic reticulum, trans-Golgi network, and endosomes. Yet, the precise site of assembly remains unresolved. Emerging evidence suggests that membrane lipid composition may play a critical role with phosphoinositides, cholesterol, and cardiolipin, alongside membrane biophysical properties and cellular metabolic state, collectively shaping membranes where inflammasome assembles.
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