Nancy Yufei Cui

1 INTRODUCTION Type 1 diabetes (T1D) is the result of a deficiency of insulin secretion caused by the autoimmune-mediated destruction of pancreatic islet beta cells.1, 2 The pathogenesis of T1D includes autoreactive immunological mechanisms involving various immune cells and mediators.3 T1D is characterised by the presence of autoantibodies to multiple islet autoantigens, which are well-established markers of islet autoimmunity.4, 5 The positive effect of immunomodulation on beta-cell...

Abstract Mammalian animal model species for preclinical drug testing share a large number of genes with similar names and/or protein primary structures, but gene expression patterns in different tissues and in response to different drugs have not been previously systematically characterized. Here, we experimentally measure the gene expression responses (reactomes) of each gene in the mouse and rat genomes in 10 different organs to 3 different drugs.