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Clinical relevance of circulating activin A and follistatin in small cell lung cancer
Highlights • ActA and FST are significantly elevated in the plasma of SCLC patients. • High plasma ActA levels correlate with extensive-stage SCLC. • Elevated ActA concentration is an independent negative prognosticator in SCLC. Abstract Objectives Circulating levels of activin A (ActA) and follistatin (FST) have been investigated in various disorders including malignancies. However, to date, their diagnostic and prognostic relevance is largely unknown in small cell lung cancer (SCLC).
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