Nannaphat Chumsri

Introduction Click to copy section linkSection link copied! Gymnothelignans are a structurally unique subclass of lignans (1) bearing a dimethyl-substituted tetrahydrofuran (THF) ring with variable conformations and stereochemistries across the THF ring. The first isolation of gymnothelignans A–O was revealed in 2012 by Xu et al.

Synthesis of Eupomatilone Skeletons 6 The synthesis of 6 commenced with the preparation of biaryl bromide 8a ( Scheme 3 A). Following the reported literature, aryl bromide 10 (36% yield) was synthesized in 3 steps starting from o -vanillin.