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Nantia Leonidou on Muck Rack

Nantia Leonidou

As seen in: Nature, PLOS, BioRxiv
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Articles

Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses - Communications Biology

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By Alina Renz, Lena Best, Georgios Marinos, Nantia Leonidou, Filipe Cabreiro, Marc Pellegrini, Andres Pizzorno, Andreas Dräger, Michael Schindler
| Nature Verified
Abstract The SARS-CoV-2 pandemic has reemphasized the urgent need for broad-spectrum antiviral therapies. We developed a computational workflow using scRNA-Seq data to assess cellular metabolism during viral infection. With this workflow we predicted the capacity of cells to sustain SARS-CoV-2 virion production in patients and found a tissue-wide induction of metabolic pathways that support viral replication.
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Exploring the metabolic profile of A. baumannii for antimicrobial development using genome-scale modeling

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By Nantia Leonidou, Antimicrobial-Resistant Pathogens, Eberhard Karl, Yufan Xia, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Leonidou N, Xia Y, Friedrich L, Schütz MS, Dräger A (2024) Exploring the metabolic profile of A. baumannii for antimicrobial development using genome-scale modeling. PLoS Pathog 20(9): e1012528.
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Exploring the metabolic profiling of A. baumannii for antimicrobial development using genome-scale modeling

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By Nantia Leonidou, Yufan Xia, Lea Friedrich, Monika Schuetz
| BioRxiv
Abstract With the emergence of multidrug-resistant bacteria, the World Health Organization published a catalog of microorganisms urgently needing new antibiotics, with the carbapenem-resistant Acinetobacter baumannii designated as "critical". Such isolates, frequentlydetected in healthcare settings, pose a global pandemic threat. One way to facilitate a systemic view of bacterial metabolism and allow the development of new therapeutics is to apply constraint-based modelling.
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