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Nanying Chen

As seen in: Wiley Online Library
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Articles

The Novel HLA-DRB4*01:03:49 Allele Was Identified by Next-Generation Sequencing

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By Yizhen He, Lina Dong, Nanying Chen
| Wiley Online Library Verified
Although the number of HLA alleles has remarkably expanded to 45421, the HLA-DRB4 locus still shows relatively low diversity, with only 357 alleles according to IPD-IMGT/HLA database (Release 3.65, July 2026) [1]. It has been reported that HLA-DRB4*01:03 is the most frequent HLA-DRB4 allele in the Chinese Han population, with a frequency of 98.11% [2].
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Identification of Two Novel HLA-DQB1 Alleles, HLA-DQB1*02:239 and HLA-DQB1*02:271

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By Wenwen Pi, Fang Wang, Nanying Chen
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are freely available in the IPD-IMGT/HLA Database. References 1, , , et al., “The IPD-IMGT/HLA Database: Recent Developments in Sequence Submission,” Nucleic Acids Research 54 (2026): D1152–D1158. 2, , , et al., “The Polymorphism of HLA-A, -C-B, -DRB3/4/5, -DRB1, -DQB1 Loci in Zhejiang Han Population, China.
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Characterisation of the Novel HLA-DQB1*05:01:56 Allele Using Next-Generation Sequencing in a Chinese Cord Blood Donor

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By Nanying Chen, Fang Wang, Wenwen Pi
| Wiley Online Library Verified
Currently, over 30,894 HLA alleles have been identified in populations around the world, including 3121 alleles for HLA-DQB1 locus according to the latest version of the IPD-IMGT/HLA Database release 3.65 version (July, 2026) [1]. HLA-DQB1*05:01 is a common allele with the frequency of 4.62% in the Chinese Han population [2].
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