Napathip Lertpreedakorn on Muck Rack

Napathip Lertpreedakorn

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Articles

Phage lysis protein LysM acts as a wedge to block MurJ conformational changes

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By Hidetaka Kohga, Napathip Lertpreedakorn, Ryoji Miyazaki, Sixian Wu
| biorxiv.org
Abstract Many antibiotics target essential cellular processes. To combat multidrug-resistant bacteria, new antibacterial strategies are needed. In the peptidoglycan biogenesis pathway in Escherichia coli, MurJ, the lipid II flippase, is an essential membrane protein. The 37-residue protein M from the Levivirus phage, known as LysM or SglM, targets MurJ and induces cell lysis; however, its molecular mechanism remains unclear.
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Critical residues of the antibiotic peptide LysM that inhibits lipid II flipping

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By Ryoji Miyazaki, Tomoya Tsukazaki, Hidetaka Kohga, Napathip Lertpreedakorn
| biorxiv.org
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