Skip To Main Content
Narasimharaju Kalidindi on Muck Rack

Narasimharaju Kalidindi

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Narasimharaju

Contact Narasimharaju, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins

|
By Anna Leder, Guillaume Mas, Mathieu Rebeaud, Siddhi Omkar, Sanjeev Uthishtran, Senthil Arumugam, Andrew W. Truman, Sebastian Hiller, Narasimharaju Kalidindi, Nadinath Bandara Nillegoda
| Nature Verified
Abstract J-domain proteins (JDPs) direct Hsp70 functions through a conserved J-domain that engages and activates Hsp70. JDPs support proteostasis and are linked to development and disease, yet how they are regulated remains unclear. Here, we identify a conserved tyrosine motif outside the canonical four-helix J-domain core, as an unexpected structural control element across the JDP family. NMR shows that phosphomimetic substitutions at these residues disrupt the J-domain fold in DNAJA1 and DNAJB1.
Open in Who Shared Issue with article?
See all 1 articles