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Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury

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By Xin Wang, Jonathan Rosand, Natalia S. Rost, Karen Furie, William J. Devan, Jing Zhou, Rose Du, Svetlana Lorenzano, Wenming Liu, Nareerat Charoenvimolphan, Baogang Qian, Jun Xu, Jian Wang, Xinmu Zhang, Annerose Berndt, Valerie J. Valant, Jinyi Wang, Robert M. Friedlander, Beverly Paigen
| stroke.ahajournals.org
Background and Purpose—The extent of ischemic injury in response to cerebral ischemia is known to be affected by native vasculature. However, the nonvascular and dynamic vascular responses and their genetic basis are not well understood. Methods—We performed a genome-wide association study in 235 mice from 33 inbred strains using the middle cerebral artery occlusion model. Population structure and genetic relatedness were accounted for using the efficient mixed-model association method.
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