Natalie L Macchi on Muck Rack

Natalie L Macchi

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Articles

Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons

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By Lucas J Handlin, Natalie L Macchi, Nicolas Dumaire, Lyuba Salih
| biorxiv.org
Abstract Cell membranes consist of heterogeneous lipid nanodomains that influence key cellular processes. Using FRET-based fluorescent assays and fluorescence lifetime imaging microscopy (FLIM), we found that the dimension of cholesterol-enriched ordered membrane domains (OMD) varies considerably, depending on specific cell types.
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Disruption of Ordered Membrane Domains as a Mechanism Underlying Neuropathic Pain

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By Lucas J Handlin, Nicolas Dumaire, Lyuba Salih, Natalie L Macchi
| biorxiv.org
Abstract Cell membranes consist of heterogeneous lipid domains that influence key cellular processes, including signal transduction, endocytosis, and electrical excitability. The goal of this study was to assess the size of cholesterol-enriched ordered membrane domains (OMD) in various cell types.
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