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Nathalia D'AGUSTINI on Muck Rack

Nathalia D'AGUSTINI

As seen in: eCancer
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Articles

Influence of proton pump inhibitors on the pathological response of rectal cancer: a multicentre study

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By Marcelle G Cesca, Erika Ruiz-Garcia, Rui F Weschenfelder, Nathalia D'AGUSTINI
| eCancer Verified
Background: The standard neoadjuvant therapy for rectal cancer involves fluoropyrimidines and radiotherapy and, most recently, total neoadjuvant therapy (TNT). A drug–drug interaction between fluoropyrimidines and proton-pump inhibitors (PPI) was suggested, with a negative impact on oncological outcomes in breast, colon and gastric cancers. Little is known about such an effect on rectal tumours.
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