Nathalie Mathy on Muck Rack

Nathalie Mathy

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A development-specific POLX essential for programmed genome rearrangement in Paramecium tetraurelia

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By Olivier Arnaiz, Coralie Zangarelli, Baptiste Verron, Nathalie Mathy
| biorxiv.org
Abstract During the sexual cycle, programmed genome rearrangement (PGR) in Paramecium tetraurelia involves the non-homologous end joining (NHEJ) DNA repair pathway to eliminate specific germinal Internal Eliminated Sequences (IESs) from the newly developing somatic nucleus. In addition to the core NHEJ factors Ku70/80 and Xrcc4/Lig4, additional enzymes are required to process the 4-base 5-protruding ends generated following DNA cleavage at IES boundaries, prior to their ligation.
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