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Articles by Nathan E. Estrin
Understanding extracellular vesicles in antiaging
1 INTRODUCTION The increasing social and economic implications of an aging world population have propelled aging-associated research into the spotlight.1 Indeed, in recent decades, advancements in medicine have significantly enhanced life expectancy globally.
Stability of 6-mm Implants Placed Crestally and Supracrestally by Surgeons of Varying Experience In Vitro
Purpose: To evaluate the importance of clinical expertise on implant stability (IS) of 6-mm implants placed in vitro. Materials and Methods: A total of 480 implants (Tapered Short Implants, BioHorizons) (6-mm length and diameters of 4.6 mm and 5.8 mm) were used in this study.
Effect of Primary Stability on Short Implants Versus Conventional Implants with a Reverse Concave Neck
Purpose: To evaluate the primary stability of short implants vs conventional implants in vitro. Materials and Methods: Two groups of implants, short implants (6.0 × 7 mm) and conventional implants (3.75 × 10 mm), with a reverse concave neck and neck microthreads (ULT, Ditron Dental) were studied. A total of 80 implants (40 short implants and 40 conventional implants) were placed by the same calibrated clinician (G.R.) at 800 rpm. Each implant was placed in hard (type 2) and soft (type 4) bone.
Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV-erything
1 INTRODUCTION Cells are recognized to secrete a wide array of vesicles, together with macromolecules and smaller molecules such as cofactors and salts, into the extracellular space. The diversity of these vesicles is based on the origin and type of cells and their present condition, for instance, stressed, stimulated, differentiated, or transformed.
Modifications to platelet-rich fibrin (PRF): From resorption of 2 weeks to 4-6 months utilizing the novel Bio-Heat technology
Abstract Platelet-rich fibrin (PRF) has been demonstrated to be an excellent biomaterial addition to most surgeries performed in dentistry owing to its excellent biocompatibility, supraphysiological concentration of autogenous cells and regenerative growth factors over time. Nevertheless, one of the main reported drawbacks of PRF is its rather fast resorption properties characterized within a two-to-three-week time frame, thus limiting its use as a “barrier: membrane in GBR/GTR procedures.
Use of horizontal centrifugation of platelet-rich fibrin leads to a 4-fold increase in cell concentration
Abstract Platelet-rich fibrin (PRF) has been utilized in implant dentistry for well over a decade owing to its ability to rapidly stimulate tissue angiogenesis and faster wound healing and recovery. Over the years, much progress has been made to more effectively concentrate platelets and growth factors as well as define their clinical use for the regeneration of both soft and hard tissues.
Bad breath advice: Can we stop the nonsense?
Bad breath advice is everywhere. Around Valentine’s Day, before job interviews, before weddings, and anytime the internet decides to recycle the same tired list of hygiene tips, patients are told to brush better, scrape their tongue, chew gum, drink water, and use mouthwash.
Safety and Feasibility of Extended Platelet‐Rich Fibrin as a Solo Barrier Membrane for Ridge Preservation: A Case Series
1 Introduction Managing extraction sites is commonly the first step prior to successful dental implant placement to limit the dimensional alterations of hard and soft tissues following tooth extractions (Becker et al. 2016).
The use of exosomes to save teeth
What you'll learn in this article Why exosomes—specifically those derived from periodontal ligament stem cells (periosomes)—are emerging as a superior alternative to stem cells for periodontal regeneration and bone healing How exosomes work at the cellular level to promote tissue repair, reduce inflammation, and regenerate lost bone around teeth affected by gum disease What clinical research and real-world cases reveal about the safety, effectiveness, and future potential of exosome-based...
International Endodontic Journal | BES Endodontology Journal | Wiley Online Library
INTRODUCTION Dental pulp represents a tissue characterized by high innervation and vascularization that plays multiple roles, including responding to bacterial invasion and injury, and facilitating the neuronal sensitivity essential for the transmission of mechanical stimuli related to repair and regeneration. Thus, the absence of this tissue leads to a decline in tooth vitality (Farges et al., 2015).
Use of Platelet‐Rich Fibrin (PRF) on Palatal Wound Healing: A Narrative Review With Clinical Recommendations
Conflicts of Interest Richard J. Miron is the founder of Miron Research and Development in Dentistry LLC, which holds intellectual property on the production of PRF. All other authors declare that they have no competing interests.
Analgesic effects of platelet‐rich fibrin (PRF): A systematic review
1 INTRODUCTION Postoperative pain management remains a critical component of patient care across a wide spectrum of medical and dental surgical procedures.
Relationship between vitamin D deficiency and early implant failure and osseointegration
1 INTRODUCTION Vitamin D is a fat-soluble secosteroid hormone obtained from the diet or synthesized endogenously in the skin through ultraviolet B (UVB) radiation.1, 2 The two major forms are vitamin D2 (ergocalciferol), derived from plant sources, and vitamin D3 (cholecalciferol), synthesized in the skin from 7-dehydrocholesterol following UVB exposure. Only cholecalciferol (vitamin D3) is endogenously produced and serves as the primary source for biological activity in humans.
Glucagon‐Like Peptide 1 Receptor Agonists (GLP‐1RAs) Improve Periodontal and Peri‐Implant Health in Type 2 Diabetes Mellitus
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jre13410-sup-0001-AppendixS1.docxWord 2007 document , 14 KB Appendix S1. References 1 Association AD, “Diagnosis and Classification of Diabetes Mellitus,” Diabetes Care 33, no. Supplement_1 (2010): S62–S69.
Potential applications of exosomes in medicine and dentistry
Potential applications of exosomes in medicine and dentistry Exosome-based therapies provide an innovative and promising approach for addressing current challenges that will help improve dental implant placement, treatment of periodontal disease, and endodontic treatments such as root canal therapy.
Use of liquid platelet‐rich fibrin (liquid PRF) in temporomandibular joint disorders: A narrative review with clinical recommendations
1 INTRODUCTION Temporomandibular joint disorders (TMD) are a prevalent and multifactorial subset of craniofacial pain conditions that affect the temporomandibular joint (TMJ), the masticatory muscles, and related musculoskeletal structures of the head and neck.1-3 Patients with TMD commonly present with symptoms such as pain, restricted or uneven mandibular movement, and joint sounds.2, 4 Treatment options for TMD range from noninvasive approaches to surgical interventions, all of which aim...
The use of exosomes to save teeth
In this article, the use of exosomes is discussed in reference to their ability to save teeth. One of the most highly published topics in regenerative medicine over the past decade has been focused on the benefits of exosome therapy over stem cells. Here, we discuss how exosomes specifically designed for periodontal regeneration (periosomes) have been found to be far superior over any other growth factor or biomaterial currently available on the market.
Potential applications of exosomes in medicine and dentistry
Introduction Exosomes are the smallest subset of extracellular vesicles that are nano-sized lipid bilayer particles secreted by nearly all cell types, serving as natural carriers of proteins, DNA, RNA, and mRNA that facilitate intercellular communication.1 Medical use of exosomes began more than 10 years ago and include improvements in tissue regeneration, neurogenesis, angiogenesis, and immune modulation.2 In dentistry, exosomes show immense promise for repairing many tissue types including...
Advantages of horizontal centrifugation of platelet-rich fibrin in regenerative medicine and dentistry
1 INTRODUCTION The utilization of autologous platelet concentrates (APCs) has gained tremendous attention over the past 25 years as an effective approach to stimulate tissue regeneration.1-8 Platelet-rich plasma (PRP) was a first-generation APC that utilized anticoagulants and favored tissue regeneration with up to a six- to eightfold increase in platelet concentrations.9-11 Initial research indicated that PRP significantly enhanced the levels of several key growth factors, including...
Bad breath caused by leaky gut: Nutrition may help both problems
198650975 © Kowniewping | Dreamstime.com Science & Tech Bad breath caused by leaky gut: Nutrition may help both problems Leaky gut is multifactorial, with nutrition being one of the more important etiologies. Drs. Scott Froum and Nathan Estrin look at the role proper nutrition plays in mitigating leaky gut and in doing so, potentially helping with halitosis.
Platelet-rich plasma (PRP) versus injectable platelet-rich fibrin (i-PRF): A systematic review across all fields of medicine
1 INTRODUCTION Autologous platelet concentrates (APCs) are increasingly popular biomaterials used in various fields of medicine owing to their ability to release supra-concentrates of autologous growth factors, including transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF).1-7 The first generation of APCs was developed in the late 1990s and termed platelet-rich plasma (PRP), a liquid form of platelet concentrates...
Periodontal regeneration using platelet‐rich fibrin. Furcation defects: A systematic review with meta‐analysis
1 INTRODUCTION Molars with classes II and III furcation defects are recognized as complexity factors for determining the stage of periodontitis in the new AAP/EFP classification of periodontal diseases.1, 2 This is due to the fact that they exhibit a higher rate of tooth loss than molars without furcation involvement3 and provide a significant challenge for the clinician to accomplish a successful treatment.4 Although access flap surgery (open flap debridement) and nonsurgical therapies have...
Bad breath caused by leaky gut: Nutrition may help both problems
Leaky gut is a condition where toxins, bacteria, and/or undigested food particles leak through a damaged part of the digestive track and enter the bloodstream, initiating an immune response that can interact with different systems of the body.
Understanding exososmes: Part 3-therapeutic + diagnostic potential in dentistry
1 INTRODUCTION Exosomes are the smallest extracellular vesicles; they range in size from 30 to 150 nm and are found in the majority of bodily fluids.1 They can transport functional miRNAs, coupled with the inherent biological functions of exosomes, which makes them a novel delivery platform for gene therapy.2 Exosomes have many advantages as new drug delivery tools—specifically, they have the characteristics of low immunogenicity and high transport efficiency, they can regulate inflammation,...
Extended platelet‐rich fibrin
1 INTRODUCTION Platelet concentrates have been utilized in many fields of regenerative medicine owing to their ability to deliver supraphysiological concentrations of autologous platelets, leukocytes and growth factors.1, 2 While platelet-rich plasma (PRP) has been extensively employed as a first generation platelet concentrate, platelet rich-fibrin (PRF) has since been utilized with a better ability to release more growth factors over an extended period of time with superior clinical...
Penetration Depth of Initiated and Non-Initiated Diode Lasers in Bovine Gingiva
Open AccessCommunication by Georgios E. Romanos 1,*, Nathan E.
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
1 INTRODUCTION Exosomes are the smallest extracellular vesicles ranging in size from 30 to 150 nm and are found in the majority of bodily fluids.1 They can transport functional miRNAs, coupled with the inherent biological functions of exosomes, which makes them a highly sought after and novel delivery platform.2 Specifically, they have the characteristics of low immunogenicity and high transport efficiency, which can regulate inflammation and cross the blood–brain barrier (BBB).3-5 They...
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