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Articles

Molecular insights into DNA damage response plasticity in glioma stem cells

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By Nathan Molinari, Andrea Bianconi, Debora Giunti, Elena Cerutti, Valeria Lusi, Daniele De Pasquale, Pietro Fiaschi
| Nature Verified
Abstract High-grade gliomas frequently recur after radiotherapy and temozolomide because tumor cells can adapt to sustained DNA damage. This Review discusses how glioma stem cells contribute to this resistance by rewiring the DNA damage response rather than simply increasing DNA repair efficiency.
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