Nathan Peter Bensler on Muck Rack

Nathan Peter Bensler

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Articles

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

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By Ankur Chakravarthy, Lubaba Khan, Nathan Peter Bensler, Pinaki Bose
| Nature
Definition of a pan-cancer ECM dysregulation profile Initially, to study ECM gene dysregulation across cancers, we defined a transcriptional signature to distinguish malignant (n = 8043) and normal tissues (n = 704) accounting for tumour type (n = 15) from TCGA and tested for enrichment of an ECM-associated gene-set we curated based on gene ontology terms (Supplementary Table 1, Supplementary Figure 1A).
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