Nathânia Dábilla

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Dunagan MM, Dábilla N, McNinch C, Brenchley JM, Dolan PT, Fox JM (2025) Interaction of the endogenous antibody response with activating FcγRs enhance control of Mayaro virus through monocytes. PLoS Pathog 21(2): e1012944. https://doi.org/10.1371/journal.ppat.1012944 Editor: Mark T.

Abstract Mayaro virus (MAYV) is an emerging arbovirus. Previous studies have shown antibody Fc effector functions are critical for optimal monoclonal antibody-mediated protection against alphaviruses; however, the requirement of Fc gamma receptors (FcγRs) for protection during natural infection has not been evaluated. Here, we showed mice lacking activating FcγRs (FcRγ-/-) developed prolonged clinical disease with more virus in joint-associated tissues.

Abstract Like all biological populations, viral populations exist as networks of genotypes connected through mutation. Mapping the topology of these networks and quantifying population dynamics across them is crucial to understanding how populations adapt to changes in their selective environment. The influence of mutational networks is especially profound in viral populations that rapidly explore their mutational neighborhoods via high mutation rates.