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Natkunam Ketheesan on Muck Rack

Natkunam Ketheesan

As seen in: Nature, Taylor & Francis Online, BioRxiv
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Articles

Determination of immune responses in mucosal lymphoid tissues following infectious laryngotracheitis virus (ILTV) eye drop and vent brush vaccination of chickens

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By Thanh Tien Tran, Nicholas M. Andronicos, Natkunam Ketheesan, Shahid Nazir
| Taylor & Francis Online
Abstract Eye drop (ED) and vent brush (VB) application of live infectious laryngotracheitis virus (ILTV) vaccine provides protective immunity against disease, but little is known regarding the immune responses following application. This study compared the gene expression of immune markers associated with VB and ED ILTV vaccination in the conjunctiva, trachea and cloaca at 3, 5, 7 and 10 days post-vaccination (dpv) and 3, 5 and 7 days post-revaccination (dprv).
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A transformative preclinical model of rheumatic heart disease - Nature Reviews Cardiology

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By Natkunam Ketheesan
| Nature Verified
Rheumatic heart disease (RHD) remains the leading cause of acquired heart disease in individuals aged >25 years. Despite being preventable, this condition affects >40 million people worldwide, particularly in low-income countries. RHD is characterized by permanent heart valve damage after a single or repeated bouts of acute rheumatic fever (ARF), a multiorgan autoimmune condition triggered by streptococcal bacterial infection that affects the heart, joints, skin and brain.
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Immunotherapeutic strategy to prevent progression and complications of acute rheumatic fever

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By Ailin Lepletier, Natkunam Ketheesan, Michael Good, Manisha Pandey
| BioRxiv
Abstract Acute rheumatic fever (ARF) is an autoimmune disease triggered by antibodies and T-cells targeting the Group A streptococcal (GAS, Strep A) bacterium, often leading to rheumatic heart disease (RHD). Long-term antibiotic therapy is recognized as a cornerstone of public health programs to prevent reinfection and progression of ARF. However, better tools to slow disease progression, and mitigate its lifelong consequences are required.
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