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Natsuo Banura

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Articles

Longitudinal characterization of tumor vascular adaptation using superfine magnetic resonance angiography

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By Xin Tian, Shigeyoshi Saito, Atsushi Mahara, Natsuo Banura
| Nature Verified
Abstract This study aimed to establish a noninvasive magnetic resonance angiography (MRA) framework for monitoring tumor vascular adaptation longitudinally using the intravascular supramolecular contrast agent 8-arm PEG-FGd3. (1) Unlike conventional Gd-chelates, which predominantly enhanced tumor tissue because of contrast extravasation, 8-arm PEG-FGd3 provided high-contrast delineation of tumor-feeding vessels and microvascular architecture, visualizing tumor vessels as small as 190 μm.
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